He was in charge of a factory in Florence but then decided to move on from the family business.
Guccio was married to Aida Calvelli in 1901, with whom he had a total of six children, five sons one of which was named Enzo, who died at the age of 9 in 1913 and a daughter.
He was the son of Tuscan parents, Gabriello Gucci, a leather craftsman from , and Elena Santini, from.